Will Anyone Consider the Ethics of Genetically Engineered Humans?

The story of the gene-edited babies birthed in China continues to reverberate around the world. To review, the Chinese scientist He Jiankui disclosed in late 2018 that he had used gene editing tools to create genetically-modified human embryos, and he then gestated the embryos to birth. He discussed his experiments on the twin girls at an international genetics meeting co-sponsored by the U.S. National Academy of Sciences. While most of the scientific community condemned the experiments, some of the outrage seemed feigned. Nonetheless, in the months following his announcement, there were calls from leading scientists and ethicists for a global moratorium on human heritable genome editing and wide-ranging discussions on the ethics of manipulating the human genome. Over 60 global leaders wrote to U.S. Department of Health and Human Services (HHS) Secretary Alex Azar, saying “We write as scientific, industry, and bioethics leaders who are committed to translating the promise of gene editing into medicines to help patients in need, to express our views strongly condemning the recent reports of the birth of CRISPR-edited infants in China and to urge you to take action.”

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Actually Making Better Human Beings

There continues to be a push to “make better human beings” using genetic modifying technologies. This includes the use of gene editing enzyme tools such as the much talked about CRISPR-Cas system, as well as large scale heritable genetic technologies such as creation of three-parent embryos. As discussed previously, one aspect of gene editing has a very positive aspect: actually attempting to treat patients with genetic conditions and other maladies. Those clinical trials include potential treatments for cancers, sickle cell disease and even the first in-body gene editing to treat blindness. These are truly therapeutic trials, attempting to alleviate diseases in affected patients.

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Who is Juan Carlos Izpisúa Belmonte?

Dr. Juan Carlos Izpisúa Belmonte is trained in pharmacy and biochemistry and is a professor at the Salk Institute for Biological Studies in La Jolla, California, in the Gene Expression Laboratories. He has been at the Salk Institute since 1993. He also held a position in Spain during 10 of those years. He helped found the Barcelona Regenerative Medicine Center (CMRB), a stem cell research institution, in 2004. He left the CMRB director’s post in 2014, citing lack of funding and support from the government. Of the center’s 21 projects, he took 18 with him, for they were his intellectual property.

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Cloning Dollars

Cloning is an extremely lucrative business that has become more efficient. In today’s blog post, Dr. David Stevens explores this topic and shares what the Bible says about cloning, as well as the moral and ethical implications of this rising business.

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The Quality Control of Life

Manufacturing industries routinely do quality control on their products, testing them to be certain the items being produced meet certain specifications. Any flawed products, those that do not meet the required specifications, are discarded. But what if that same mindset were applied to human beings?

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Gene Editing to Make Better Human Beings?

Gene editing has potential for great benefit but also for great evil. In the medical realm, great advances are possible, but this dual-use technology also could be used to design children, weaponize biological agents or even alter or dehumanize our concept of humanity. Dr. David Prentice explores how gene editing can be dangerous for healthcare professionals and their patients in this week’s blog post.

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British Scientists to Genetically Modify Human Embryos

It remains illegal for these genetically altered embryos to be implanted in a woman. It is hoped the experiments will improve our understanding of the earliest stages of embryo development. The research, which was approved by the Human Fertilization and Embryology Authority, will use excess embryos donated by couples who have had in vitro fertilization treatment.

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The Point Washington Update – April 2014

Commentary and update on the state of legislative activities in Washington involving CMDA member interests. In this edition of The Point: Researchers harvest stem cells from cloned human embryos, Assisted suicide advocates make their case in JAMA, and SCOTUS hears case on free speech re: abortion in Obamacare.

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The Point Blog – May 2013

In this edition of The Point: CMDA physicians on human cloning study revelation, Vermont to legalize physician-assisted suicide, Use Of Embryo Donation As A Family Building Option.

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Cloning Name Games

Proponents of therapeutic cloning seek to clone human embryos, but don’t want them implanted into women. Instead, they want to use them to produce stem cells that might some day be developed into therapies. These stem cells and resulting tissues would be immunologically compatible with the person from whom they were cloned, thereby overcoming the risk of rejection that plagues tissue transplantation from other people.

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